Research conducted in the Keillor Lab can be divided into two areas. The first touches on several aspects of enzymology 鈥 studying the detailed mechanisms by which enzymes function, synthesizing and testing inhibitors with therapeutic potential, and engineering enzymes for practical catalytic applications. The second area involves the development of methods for labelling specific proteins in living cells, for the subsequent study of their structure, localisation and trafficking. The methodology used in the Keillor Lab for both of these two lines of research comprises several different disciplines, including organic synthesis, molecular biology and the spectroscopy implicated in detailed kinetic studies.
Selected publications
-
S. K. I. Watt, J. G. Charlebois, C. N. Rowley, J. W. Keillor: 鈥淎 mechanistic study of thiol addition to N-补肠谤测濒辞测濒辫颈辫别谤颈诲颈苍别鈥, Org. Biomol. Chem. 2023, 21, 2204-2212.
-
E. W. J. Gates, K. Mansour, S. E. Samani, S. Shad, M. T. Kaartinen, J. W. Keillor: 鈥淧eptidic Inhibitors and Fluorescent Probe for the Selective Inhibition and Labelling of Factor XIIIa 罢谤补苍蝉驳濒耻迟补尘颈苍补蝉别鈥, Molecules 2023, 28, 1634.
-
N. M. R. McNeil, N. Firoozi, E. W. J. Gates, N. J. Cundy, J. Leccese, S. Eisinga, J. D.A. Tyndall, G. Adhikary, R. L. Eckert, J. W. Keillor: 鈥淪tructure-Activity Relationships of N-Terminal Variants of Peptidomimetic Tissue Transglutaminase Inhibitors鈥, Eur. J. Med. Chem. 2022, 232, 114172-114195.
-
K. K. Tsao, A. C. Lee, K. 脡. Racine, J. W. Keillor : 鈥淪ite-specific fluorogenic protein labelling agent for bioconjugation鈥, Biomolecules 2020, 10, 369-384.
-
S. K. Oteng-Pabi, C. M. Clouthier, J. W. Keillor : 鈥淒esign of a Glutamine Substrate Tag Enabling Protein Labelling Mediated by Bacillus subtilis 罢谤补苍蝉驳濒耻迟补尘颈苍补蝉别鈥, PLoS ONE 2018, 13, e0197956.