Biography
After earning his bachelor鈥檚 degree in Food Sciences (Universit茅 d鈥櫭塼at d鈥橦a茂ti), Dr. Dort was awarded several international scholarships to pursue a master鈥檚 degree at the Universit茅 Catholique de Louvain, in Belgium, and a PhD at Universit茅 Laval, in Canada. Following his Ph. D, he worked as a nutrition consultant for several international non-profit organizations, such as HarvestPlus, which implement programs to enhance food security in Haiti. Then, Dr Dort completed a postdoctoral training at the CHU Sainte-Justine Research Center in Dr Nicolas Dumont鈥檚 lab, where he investigated therapeutic compounds that target inflammation and muscle stem cell dysfunction with the goal of treating muscular dystrophies. His research was supported by fellowships from the Muscular Dystrophy Association and AFM-Telethon
Expertise
- Muscle regeneration
- Pharmacotherapy
- Nutrition
- Food security
Publications
- Soulez M, Tanguay PL, D么 F, Crist C, Dort J, Kotlyarov A, Gaestel M, Dumont NA, Meloche, S. Erk3鈥怣K5 signaling regulates myogenic differentiation and muscle regeneration by promoting FOXO3 degradation. Journal of Cellular Physiology. 2022;237(4):2271-2287. doi:10.1002/jcp.30695
- Dort J, Orfi Z, Fabre P, et al. Resolvin-D2 targets myogenic cells and improves muscle regeneration in Duchenne muscular dystrophy. Nature Communications. 2021;12(1). doi:10.1038/s41467-021-26516-0
- Deprez A, Orfi Z, Radu A, Ying H, Dartora DR, Dort J, Dumont NA, Nuyt AM. Transient neonatal exposure to hyperoxia, an experimental model of preterm birth, leads to skeletal muscle atrophy and fiber type switching. Clinical Science. 2021. doi:10.1042/cs20210894
- Dort J, Fabre P, Molina T, Dumont NA. Macrophages are key regulators of stem cells during skeletal muscle regeneration and diseases. Stem Cells International. 2019;2019:1-20. doi:10.1155/2019/4761427
- Feitchinger RG, Mucha B, Orfi Z, Hengel H, Dort J et al. Biallelic variants in the transcription factor PAX7 are a new genetic cause of myopathy. Genetics in Medicine. 2019;21(11):2521-2531. doi:10.1038/s41436-019-0532-z
- Mellery J, Brel J, Dort J, et al. An-3 PUFA depletion applied to rainbow trout fry (oncorhynchus mykiss) does not modulate its subsequent lipid bioconversion capacity. British Journal of Nutrition. 2017;117(2):187-199. doi:10.1017/s0007114516004487
- Dort J, Leblanc N, Bryl P, et al. Shrimp protein hydrolysate modulates the timing of proinflammatory macrophages in bupivacaine-injured skeletal muscles in rats. BioMed Research International. 2016;2016:1-13. doi:10.1155/2016/5214561
- Anderson, J, Do, MK; Suzuki, T; Daneshvar, N; Dort, J; Mizunoya, W; Tatsumi, R. The role of Semaphorin3a in myogenic regeneration and the formation of functional neuromuscular junctions on New Fibres. Biological Reviews. 2016;92(3):1389-1405. doi:10.1111/brv.12286
- Jensen I-J, Dort J, Eilertsen K-E. Proximate composition, antihypertensive and antioxidative properties of the semimembranosus muscle from pork and beef after cooking and in vitro digestion. Meat Science. 2014;96(2):916-921. doi:10.1016/j.meatsci.2013.10.014
- Dort J, Leblanc N, Maltais-Gigu猫re J, Liaset B, C么t茅 CH, Jacques H. Beneficial effects of cod protein on inflammatory cell accumulation in rat skeletal muscle after injury are driven by its high levels of arginine, glycine, taurine and lysine. PLoS ONE. 2013;8(10). doi:10.1371/journal.pone.0077274
- Dort J, Sirois A, Leblanc N, C么t茅 CH, Jacques H. Beneficial effects of cod protein on skeletal muscle repair following injury. Applied Physiology, Nutrition, and Metabolism. 2012;37(3):489-498. doi:10.1139/h2012-021
Awards and Nominations
- Development grant (2021-2024), Muscular Dystrophy Association
- Postdoctoral fellowship. (2020-2022), French Muscular Dystrophy Association
- Postdoctoral fellowship for excellence (2017-2019), Sainte-Justine Foundation
- Doctoral award (2009-2011), Organization of American States
- Master award (2008-2009), University Commission for Development, Belgium